How Old is Old for Transplantation

作者: Gabriel C. Oniscu , Helen Brown , John L. Forsythe

DOI: 10.1111/J.1600-6143.2004.00622.X

关键词: ComorbidityIncidence (epidemiology)Survival analysisTransplantationSurgeryDelayed Graft FunctionMultivariate analysisSocial deprivationPediatricsMedicineGraft survival

摘要: Elderly patients are the fastest growing group requiring renal transplantation. This study investigates whether transplantation is worthwhile in elderly and there evidence supporting an age limit for One thousand ninety-five adults transplanted Scotland between 1 January 1989 31 December 1999 were followed up to 11 years. Sociodemographic, comorbidity transplant data obtained from national databases patient's notes. Patient graft survival, risk causes of failure patient death compared four groups (18-49, 50-59, 60-64 >65). All had similar gender, social deprivation disease distribution. The incidence increased with age. comparable HLA matching, but aged 18-49 years received transplants younger donors shorter cold ischaemic times. Younger more acute rejection less delayed function. Older a higher functioning graft. Patients over 65 almost dialysis-free remaining life, while half-life was significantly than youngest group. Transplantation recipients despite comorbidity. Careful selection rather fixed should be used ensure satisfactory survival.

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