Schizotypy-related magnetization of cortex in healthy adolescence is co-located with expression of schizophrenia risk genes
作者： Rafael Romero-Garcia , Jakob Seidlitz , Kirstie J Whitaker , Sarah E Morgan , Peter Fonagy
DOI: 10.1101/487108
关键词: Precuneus 、 Cortex (anatomy) 、 Prefrontal cortex 、 Neuroscience 、 Default mode network 、 Parvalbumin 、 Schizophrenia 、 Posterior cingulate 、 Biology 、 Schizotypy
摘要: Background: Genetic risk is thought to drive clinical variation on a spectrum of schizophrenia-like traits but the underlying changes in brain structure that mechanistically link genomic schizotypal experience and behaviour are unclear. Methods: We assessed schizotypy using self-reported questionnaire, measured magnetization transfer (MT), as putative micro-structural MRI marker intra-cortical myelination, 68 regions, 248 healthy young people (aged 14-25 years). We used normative adult gene expression data, partial least squares (PLS) analysis, find weighted pattern was most co-located with cortical map schizotypy-related (SRM). Results: Magnetization significantly correlated bilateral posterior cingulate cortex precuneus (and for disorganized also medial prefrontal cortex; all FDR-corrected P < 0.05), which regions default mode network specialized social memory functions. The genes positively whole genome SRM were enriched down-regulated two prior case-control histological studies schizophrenia. Conversely, negatively transcriptionally up-regulated Positively (down-regulated) neuronal, specifically inter-neuronal, affiliations coded proteins comprising few highly interactive -hubs- such parvalbumin calmodulin. Conclusions: Microstructural maps intracortical can be linked both behavioural data dysregulated
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