Meta-analysis of genetic association studies on bipolar disorder.

摘要: Numerous candidate gene association studies of bipolar disorder (BP) have been carried out, but the results inconsistent. Individual are typically underpowered to detect associations with genes small effect sizes. We conducted a meta-analysis published evaluate cumulative evidence. systematically searched for all BP. then out random-effects on polymorphisms that were reported by three or more case–control studies. The from meta-analyses these compared findings recent mega-analysis eleven genome-wide (GWAS) in BP performed Psychiatric GWAS Consortium (PGC). A total 487 articles included our review. Among these,33 polymorphismsin 18genes and meta-analysis. Polymorphisms BDNF, DRD4, DAOA, TPH1, found be nominally significant P-value < 0.05. However, none after correction multiple testing. Moreover, PGC-BP GWAS. number plausible previously associated lack robust review highlights need atheoretical approaches study genetics afforded this other on-going genomic experiments available online at Metamoodics (http://metamoodics.igm.jhmi.edu).