Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior.

摘要: Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin growth family, has been implicated in both mood disorders and suicidal behavior. This study examined association between BDNF gene Val66Met polymorphism disorders, age onset behavior Chinese sample population. The genotype allele frequencies for did not differ comparing depression groups (total, bipolar disorder or major depression) control subjects. Furthermore, it was demonstrated that this associated with history our patients. Based on these results, seems reasonable to suggest is unlikely play role genetic susceptibility disorders. Given fact positive only Caucasian population but Japanese analog sample, appears likely ethnicity dependent.