Phenotypic dissection of mood disorder

摘要: The pathogenesis of affective disorders is not clearly understood and the diagnostic validity psychiatric remains unclear. aim this thesis was to identify sub-phenotypes in that may be biologically validated by future molecular genetic studies. dataset comprised over 1000 subjects meeting criteria (DSM-IV) for bipolar I disorder (BPI) or major recurrent depression (MDDR) who were previously recruited as part ongoing Subjects had been assessed detail using Schedules Clinical Assessment Neuropsychiatry (SCAN) case-note reviews. undertook hypotheses testing exploratory analyses a range univariate multivariate statistical tests. found depressive episode at illness onset BPI associated with more course illness. also clinical characteristics bipolar, rather than unipolar, Using HCL-32, identified substantial number MDDR (17%) reported symptoms level similar subjects. significant differences according lifetime presence panic attacks, well appeared attacks only In unipolar sample, within psychotic episodes tended severe non-psychotic episodes. However, between there wide variation severity both those did, did not, experience subjects, postpartum clustered families (p=0.015). no evidence familiality reporting life events sample. These studies use