PSYCHONEUROENDOCRINOLOGY OF DEPRESSION

作者: Elizabeth Young , Ania Korszun

DOI: 10.1016/S0193-953X(05)70007-1

关键词: Internal medicineEstrogenNeuroendocrinologyHormoneMoodPsychologyEndocrinologyDepression (differential diagnoses)AmenorrheaHypothalamic–pituitary–gonadal axisPsychoneuroendocrinologyPsychiatry and Mental health

摘要: Women are more susceptible than men to depression, particularly during periods of rapid fluctuation gonadal hormones, such as premenstrually, postpartum, and the climacteric. This review summarizes evidence for association depression with abnormalities in reproductive hormones. Although there similarities stress hormones changes between depressed women stress-related amenorrhea, no LH activity have been documented depression. Similarly LH, estradiol, or progesterone premenstrual syndrome (PMS), although complete elimination monthly cycling leuprolide improves mood. Some studies suggested beneficial effects estrogen on mood postmenopausal but yet adequately controlled treatment either premenopausal women.

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