Inositol phospholipid and tyrosine phosphorylation signaling in the biology of hematopoietic stem cells
作者： Amy L. Hazen
DOI:
关键词: PI3K/AKT/mTOR pathway 、 Bone marrow 、 Hematopoietic stem cell 、 Cell biology 、 Stem cell 、 Haematopoiesis 、 Homing (hematopoietic) 、 Induced pluripotent stem cell 、 Tyrosine phosphorylation 、 Biology
摘要: Blood cells are continuously produced throughout our lifetime by a rare pluripotent cell that primarily resides in the adult bone marrow. This hematopoietic stem (HSC) must maintain careful balance between selfrenewal, differentiation and apoptosis order to support hematopoiesis for such long duration. Understanding mechanism of these fates is crucial understanding clinical application cells. From previous studies, we know Src homology 2 domain containing 5’ inositol phosphatase 1 (SHIP) plays an important role HSC homeostasis function. Most interestingly SHIP impacts homing marrow niche. An ideal location environment essential fulfill their physiological roles. Here present evidence expressed Furthermore, deficiency severely alters this thus damages
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