Studies of carbonyl sulfide toxicity: Metabolism by carbonic anhydrase
作者： Christopher P. Chengelis , Robert A. Neal
DOI: 10.1016/0041-008X(80)90236-7
关键词: Acetazolamide 、 Carbonyl sulfide 、 Metabolism 、 Carbonic anhydrase 、 Sodium nitrite 、 Nuclear chemistry 、 Hydrogen sulfide 、 Chemistry 、 Organic chemistry 、 Toxicity 、 Median lethal dose 、 Toxicology 、 Pharmacology
摘要: Abstract Carbonyl sulfide (COS) is acutely toxic to rats, with an LD 50 of 22.5 mg/kg, ip. COS partly metabolized in vivo hydrogen sulfide. Pretreatment rats acetazolamide, inhibitor carbonic anhydrase, reduced the blood levels and, concomitantly, decreased toxicity COS. Sodium nitrite pretreatment also protected animals against toxicity. Acetazolamide had no effect on per se. The results are consistent hypothesis that by and it produced responsible for
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