All-trans retinoic acid enhances murine dendritic cell migration to draining lymph nodes via the balance of matrix metalloproteinases and their inhibitors.

摘要: Cancers escape immune surveillance through the manipulation of host's system. Sequestration dendritic cells (DCs) within tumor tissues and subsequent inhibition their migration is one several mechanisms by which tumors induce immunosuppression. In view recent findings depicting improvement responses in cancer patients following all-trans retinoic acid (ATRA) treatment, we sought to identify effects ATRA on DC mobility context immunotherapy. Our results demonstrate that ATRA, added differentiating murine bone marrow progenitor cells, enhances invasive capacity resulting DCs. Immature DCs injected intratumorally mice show increased accumulation draining lymph nodes, but not nondraining nodes spleens, when differentiated presence ATRA. The vitro mature basement membrane matrix toward lymphoid chemokines CCL19 CCL21 enhanced these albeit a metalloproteinase (MMP) inhibitor. An increase MMP production with simultaneous decrease inhibitors (tissue or TIMPs) provoked This affects MMP/TIMP balance DCs, particular MMP-9 TIMP-1, favoring protease activity thus allowing for mobilization. conclusion, this study demonstrates capable improving trafficking milieu and, encouraging obtained clinic, further supports notion might be valuable chemical adjuvant current immunotherapeutic strategies cancer.