All-trans-Retinoic Acid Eliminates Immature Myeloid Cells from Tumor-bearing Mice and Improves the Effect of Vaccination

摘要: Tumor-induced immunosuppression is one of the crucial mechanisms tumor evasion immune surveillance. It contributes greatly to failure cancer vaccines. Immature myeloid cells (ImCs) play an important role in tumor-induced immunosuppression. These accumulate large numbers tumor-bearing hosts and directly inhibit T-cell functions via various mechanisms. In this study, we tried eliminate ImCs attempt improve antitumor response. vivo administration all-trans-retinoic acid (ATRA) dramatically reduced presence all tested models. This effect was not because a direct ATRA or decreased production growth factors by cells. Experiments with adoptive transfer demonstrated that differentiated ImC into mature dendritic cells, macrophages, granulocytes. Decreased mice noticeably improved CD4- CD8-mediated tumor-specific Combination two different types vaccines models significantly prolonged treatment. data suggest elimination may open opportunity