Cancer Immune Modulation and Immunosuppressive Cells: Current and Future Therapeutic Approaches
作者： Maria Stella Sasso , Vincenzo Bronte , Ilaria Marigo
DOI: 10.1007/978-3-319-08084-0_7
关键词: Cancer research 、 Myeloid 、 Innate immune system 、 Medicine 、 Immune system 、 Cancer 、 Metastasis 、 Cancer immunotherapy 、 Immune modulation 、 Suppressor
摘要: In the last decade, role of immune system in cancer pathology has received growing attention. Immune populations, such as T and B lymphocytes, NK cells, macrophages, are able to mount an anti-tumor response, which can impair tumor growth. Nonetheless, progression is usually associated with expansion additional cell subsets that inhibit natural immunity tumors actively support growth, invasion, metastasis. Their presence represents obstacle effectiveness immunotherapy. Cells myeloid origin strong immunosuppressive tumor-promoting properties, myeloid-derived suppressor cells (MDSCs) tumor-associated macrophages (TAMs), major players this process.
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