Angiotensin converting enzyme: induction by steroids in rabbit alveolar macrophages in culture.
作者： J Friedland , C Setton , E Silverstein
关键词: Steroid 、 Cycloheximide 、 Endocrinology 、 Stimulation 、 Dexamethasone 、 Blood pressure control 、 Enzyme assay 、 Internal medicine 、 Transcription (biology) 、 Angiotensin-converting enzyme 、 Biology
摘要: Dexamethasone and prednisone in physiologic range increased angiotensin converting enzyme 7- to 16-fold comparison control 3 days at maximal stimulation (4 nM steroid) rabbit alveolar macrophages culture. The increase was inhibited by actinomycin D (0.1 microng/ml) 1 micronM cycloheximide, suggesting that de novo transcription synthesis are responsible for the activity. This result is evidence a regulatory mechanism enzyme, which important blood pressure control.
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