Production of angiotensin I converting enzyme by liver granuloma macrophages of Schistosoma mansoni infected mice

摘要: Abstract Angiotensin I converting enzyme activity is detectable in serum and isolated liver granulomas of mice infected with Schistosoma mansoni . At the chronic phase infection (20 wk) intensity granulomatous response spontaneously diminishes. Concomitantly, an increase angiotensin observed. The objective this investigation was to determine source elevated activity. In chronically mice, measurements showed that hepatic venous blood higher than peripheral blood. contrast, normal demonstrated no difference regional Isolated cultured vitro released into culture medium. When were dispersed single cell suspension, traced adherent fraction. Both cells from secreted far more those animals acute (8 infection. Cycloheximide partially inhibited release. We conclude murine schistosomiasis, produced by granuloma macrophage. circulation probably resulting increased role within lesion as well remains be elucidated.