Angiotensin II binding to human mononuclear cells.

摘要: Serum angiotensin converting enzyme activity is elevated in certain human granulomatous diseases. Angiotensin II modestly suppresses thymidine incorporation and augments gamma interferon production from blood mononuclear cells. This suggests that may play an immunoregulatory role inflammation. For this reason, the binding of to peripheral mixed cells, monocyte-like cell line, U-937, was studied. U-937 cells reveals a low level saturable specific (Kd = 3 x 10(-10) M). However, not easily reversible poorly inhibited competitive manner. In addition, molecular integrity radioligand maintained following binding. Therefore, definition classical receptor cannot be fulfilled. Since decreased by temperatures various metabolic inhibitors, it appears likely endocytosis occurs, perhaps along with or its breakdown products modulate monocyte cAMP spite inability demonstrate surface receptors.