Wip1-Dependent Signaling Pathways in Health and Diseases

摘要: Spatial and temporal regulation of protein phosphorylation is key to the control different molecular networks. This achieved in part through dephosphorylation numerous signaling molecules, emerging evidence highlights importance a new member PP2C family phosphatase, Wild-type p53 induced phosphatase 1 (Wip1), regulating stress-induced DNA damage-induced In recent years, analysis Wip1 has focused primarily on its role tumorigenesis because overexpression human tumors profound tumor-resistant phenotype Wip1-deficient mice. Recently, also been shown play an important several physiological processes including adult neurogenesis organismal aging. review addresses how regulates networks spatial manner these differences contribute various biological outcomes context pathological conditions.