The Mycobacterium tuberculosis Very-Long-Chain Fatty Acyl-CoA Synthetase: Structural Basis for Housing Lipid Substrates Longer than the Enzyme.

作者: Charlotta S. Andersson , Camilla A.K. Lundgren , Auður Magnúsdóttir , Changrong Ge , Åke Wieslander

DOI: 10.1016/J.STR.2012.03.012

关键词: BiochemistryVirulencePathogenDNA ligaseIntracellularVery long chainBiologyOperonMicrobiologyEnzymeMycobacterium tuberculosis

摘要: The Mycobacterium tuberculosis acid-induced operon MymA encodes the fatty acyl-CoA synthetase FadD13 and is essential for virulence intracellular growth of pathogen. Fatty syntheta ...

参考文章(52)
Anastassis Perrakis, Richard Morris, Victor S. Lamzin, Automated protein model building combined with iterative structure refinement. Nature Structural & Molecular Biology. ,vol. 6, pp. 458- 463 ,(1999) , 10.1038/8263
Ruth E Gimeno, None, Fatty acid transport proteins Current Opinion in Lipidology. ,vol. 18, pp. 271- 276 ,(1999) , 10.1097/MOL.0B013E3281338558
Devinder Kaur, Marcelo E. Guerin, Henrieta Škovierová, Patrick J. Brennan, Mary Jackson, Chapter 2: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis. Advances in Applied Microbiology. ,vol. 69, pp. 23- 78 ,(2009) , 10.1016/S0065-2164(09)69002-X
Pankaj Khurana, Rajesh S Gokhale, Debasisa Mohanty, Genome scale prediction of substrate specificity for acyl adenylate superfamily of enzymes based on active site residue profiles. BMC Bioinformatics. ,vol. 11, pp. 57- 57 ,(2010) , 10.1186/1471-2105-11-57
Ramandeep Singh, Amit Singh, Anil K Tyagi, Deciphering the genes involved in pathogenesis of Mycobacterium tuberculosis Tuberculosis. ,vol. 85, pp. 325- 335 ,(2005) , 10.1016/J.TUBE.2005.08.015
Mark A. Fisher, Bonnie B. Plikaytis, Thomas M. Shinnick, Microarray Analysis of the Mycobacterium tuberculosis Transcriptional Response to the Acidic Conditions Found in Phagosomes Journal of Bacteriology. ,vol. 184, pp. 4025- 4032 ,(2002) , 10.1128/JB.184.14.4025-4032.2002
Changrong Ge, Alexander Georgiev, Anders Öhman, Åke Wieslander, Amélie A. Kelly, Tryptophan residues promote membrane association for a plant lipid glycosyltransferase involved in phosphate stress Journal of Biological Chemistry. ,vol. 286, pp. 6669- 6684 ,(2011) , 10.1074/JBC.M110.138495
Pooja Arora, Aneesh Goyal, Vivek T Natarajan, Eerappa Rajakumara, Priyanka Verma, Radhika Gupta, Malikmohamed Yousuf, Omita A Trivedi, Debasisa Mohanty, Anil Tyagi, Rajan Sankaranarayanan, Rajesh S Gokhale, None, Mechanistic and functional insights into fatty acid activation in Mycobacterium tuberculosis Nature Chemical Biology. ,vol. 5, pp. 166- 173 ,(2009) , 10.1038/NCHEMBIO.143
Paul A. Watkins, Very-long-chain Acyl-CoA Synthetases * Journal of Biological Chemistry. ,vol. 283, pp. 1773- 1777 ,(2008) , 10.1074/JBC.R700037200
C. Hoffmann, A. Leis, M. Niederweis, J. M. Plitzko, H. Engelhardt, Disclosure of the mycobacterial outer membrane: cryo-electron tomography and vitreous sections reveal the lipid bilayer structure. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 3963- 3967 ,(2008) , 10.1073/PNAS.0709530105