Hexaminecobalt (III) chloride and ruthenium red inhibited calcium uptake in nervous tissue
作者： George D. Williamson
DOI:
关键词: Chloride 、 Mitochondrial respiration 、 Stimulation 、 Biochemistry 、 Mitochondrial protein 、 Ruthenium red 、 Nervous tissue 、 Chemistry 、 Respiration 、 Calcium uptake
摘要: BIOLOGY George D. Williamson B.S., Morehouse College, 1980 HEXANINECOBALT(III) CHLORIDE AND RUTHENIUM RED INHIBITED CALCIUM UPTAKE IN NERVOUS TISSUE Advisor: Dr. Cyril L. Moore Thesis dated: July, 1991 The effects of ruthenium red and hexaminecobalt (III) chloride on Ca2+ transport mitochondrial respiration were studied. Low levels (3-6 nmoles/ng protein) completely inhibited the stimulation by Ca2~ but had no effect State 3 respiration. Ruthenium also respiration-dependent ATP-supported uptake as well metabolism-independent highand low-affinity binding Ca2~; although, neither an release accumulated Ca2+. Concentrations higher than (7 nmoles/mg prevent transport; markedly inhibit/alter (state 4) respirations, however, did not ADP. HEXAMINECOBAIJT INHIBITION OF A THESIS SUBMITTED TO THE FACULTY CLARK ATLANTA UNIVERSITY PARTIAL FULFILLMENT REQUIREMENTS FOR DEGREE MASTER SCIENCE r BY GEORGE DONALD WILLIAMSON DEPARTMENT ATLANTA, GEORGIA JULY
参考文章(39)
Britton Chance, Gunnar Hollunger, The interaction of energy and electron transfer reactions in mitochondria. I. General properties and nature of the products of succinate-linked reduction of pyridine nucleotide. Journal of Biological Chemistry. ,vol. 236, pp. 1534- 1543 ,(1961) , 10.1016/S0021-9258(18)64210-3
Robert H. Roth, Advances in Cytopharmacology Yale Journal of Biology and Medicine. ,vol. 46, pp. 152- 152 ,(1973)
Ronald P. Rubin, Calcium and the Secretory Process ,(1974)
Mordecai P. Blaustein, The interrelationship between sodium and calcium fluxes across cell membranes Reviews of Physiology, Biochemistry and Pharmacology. ,vol. 70, pp. 33- 82 ,(1974) , 10.1007/BFB0034293
R C Thomas, Electrogenic sodium pump in nerve and muscle cells. Physiological Reviews. ,vol. 52, pp. 563- 594 ,(1972) , 10.1152/PHYSREV.1972.52.3.563
M. P. Blaustein, W. P. Wiesmann, Effect of sodium ions on calcium movements in isolated synaptic terminals. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 66, pp. 664- 671 ,(1970) , 10.1073/PNAS.66.3.664
R. Rahamimoff, E. Alnaes, Inhibitory Action of Ruthenium Red on Neuromuscular Transmission Proceedings of the National Academy of Sciences of the United States of America. ,vol. 70, pp. 3613- 3616 ,(1973) , 10.1073/PNAS.70.12.3613
Robert J. Person, Jaquelyn A. Kuhn, Depression of spontaneous and lonophore-induced transmitter release by ruthenium red at the neuromuscular junction☆ Brain Research Bulletin. ,vol. 4, pp. 669- 674 ,(1979) , 10.1016/0361-9230(79)90111-4
P. Gloor, Epileptogenic Action of Penicillin Annals of the New York Academy of Sciences. ,vol. 166, pp. 350- 360 ,(1969) , 10.1111/J.1749-6632.1969.TB54287.X
Ronald J Racine, Modification of seizure activity by electrical stimulation. I. After-discharge threshold. Electroencephalography and Clinical Neurophysiology. ,vol. 32, pp. 269- 279 ,(1972) , 10.1016/0013-4694(72)90176-9