The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria
作者： Dominique Pessayre , Françoise Degoul , Angela Sutton , Hania Khoury , Claude Cepanec
DOI: 10.1097/01.FPC.0000054067.64000.8F
关键词: Enzyme 、 Nucleic acid sequence 、 Alcoholic liver disease 、 Superoxide dismutase 、 Molecular biology 、 Alanine 、 Fusion protein 、 Mitochondrion 、 Valine 、 Biology
摘要: A genetic dimorphism encodes for either alanine (Ala) or valine (Val) in the mitochondrial targeting sequence (MTS) of human manganese superoxide dismutase (MnSOD) and has been reported to modulate risk some cancers, neurodegenerative diseases severe alcoholic liver disease. Although func
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