摘要: Lung cancer is one of the leading causes death all over world. Although it known that genetic and epigenetic susceptibility factors play a role in determining individual risk developing lung cancer, genetically determined host occupational exposure-related poorly explored. Gene variants might affect to fall into three categories: rare-risk, moderate-risk, common low-risk variants. Most for likely involve several genes last two categories. Such have mostly been tested on candidate gene basis. However, during recent years genome-wide association studies provided an alternative these studies. This chapter presents nowadays most commonly used approaches main results they produced regarding cancer.
springer.com
sci-hub.st 参考文章(200)
Jun Yokota, Kouya Shiraishi, Takashi Kohno, Genetic basis for susceptibility to lung cancer: Recent progress and future directions. Advances in Cancer Research. ,vol. 109, pp. 51- 72 ,(2010) , 10.1016/B978-0-12-380890-5.00002-8
Arvind P. Singh, Mohan C. Pant, Munindra Ruwali, Parag P. Shah, Rajendra Prasad, Neeraj Mathur, Devendra Parmar, Polymorphism in cytochrome P450 1A2 and their interaction with risk factors in determining risk of squamous cell lung carcinoma in men. Cancer Biomarkers. ,vol. 8, pp. 351- 359 ,(2011) , 10.3233/CBM-2011-0224
Y Ohta, H Sasabe, H U Etter, S Kawato, C Richter, K H Winterhalter, Rotation and interaction with epoxide hydrase of cytochrome P-450 in proteoliposomes Journal of Biological Chemistry. ,vol. 266, pp. 18600- 18605 ,(1991) , 10.3929/ETHZ-A-000692255
Loïc Le Marchand, Chuanfa Guo, Simone Benhamou, Christine Bouchardy, Ingolf Cascorbi, Margie L Clapper, Seymour Garte, Aage Haugen, Magnus Ingelman-Sundberg, Masahiro Kihara, Agneta Rannug, David Ryberg, Isabelle Stücker, Haruhiko Sugimura, Emanuela Taioli, Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States). Cancer Causes & Control. ,vol. 14, pp. 339- 346 ,(2003) , 10.1023/A:1023956201228
Nick Orr, Stephen Chanock, Chapter 1 Common Genetic Variation and Human Disease Advances in Genetics. ,vol. 62, pp. 1- 32 ,(2008) , 10.1016/S0065-2660(08)00601-9
Mrozikiewicz Pm, Bauer S, Brockmöller J, Cascorbi I, Loddenkemper R, Roots I, Homozygous Rapid Arylamine N-Acetyltransferase (NAT2) Genotype as a Susceptibility Factor for Lung Cancer Cancer Research. ,vol. 56, pp. 3961- 3966 ,(1996)
Harri Vainio, John D. Hayes, Sisko Anttila, Kirsti Husgafvel-Pursiainen, Ari Hirvonen, Brian Ketterer, Immunohistochemical Localization of Glutathione S-Transferases in Human Lung Cancer Research. ,vol. 53, pp. 5643- 5648 ,(1993)
Dominique Pessayre, Françoise Degoul, Angela Sutton, Hania Khoury, Claude Cepanec, Carina Prip-Buus, The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria Pharmacogenetics. ,vol. 13, pp. 145- 157 ,(2003) , 10.1097/01.FPC.0000054067.64000.8F
Ana Janićijević, Kaoru Sugasawa, Yuichiro Shimizu, Fumio Hanaoka, Nils Wijgers, Miodrag Djurica, Jan HJ Hoeijmakers, Claire Wyman, DNA bending by the human damage recognition complex XPC-HR23B. DNA Repair. ,vol. 2, pp. 325- 336 ,(2003) , 10.1016/S1568-7864(02)00222-7
S Pemble, K R Schroeder, S R Spencer, D J Meyer, E Hallier, H M Bolt, B Ketterer, J B Taylor, Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochemical Journal. ,vol. 300, pp. 271- 276 ,(1994) , 10.1042/BJ3000271