Homozygous Rapid Arylamine N-Acetyltransferase (NAT2) Genotype as a Susceptibility Factor for Lung Cancer
作者： Mrozikiewicz Pm , Bauer S , Brockmöller J , Cascorbi I , Loddenkemper R
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摘要: The polymorphic arylamine N-acetyltransferase (NAT2) is supposed to be a susceptibility factor for certain malignancies. A phenotyping study in 389 lung cancer patients revealed similar distribution of rapid and slow acetylators by the caffeine test that 657 reference subjects (odds ratio, 1.05; 95% confidence limits, 0.81, 1.36; not significant). separate group 155 was studied genotyping NAT2 compared with matched 310 unrelated 278 healthy volunteers. genotype characterized PCR-RFLP at nucleotide positions 191, 282, 341, 481, 590, 803, 857. For evaluation 3'-mismatch primer used. Homozygous wild-type genotypes NAT2*4/*4 were confirmed DNA sequencing. Genotypes acetylation amounted 43.9% among 41.6% 1.10 0.73, 1.65; Discrimination into homozygous heterozygous carriers allele NAT2*4 distinct over-representation amid 2.36; 1.05, 5.32; P = 0.018). Logistic regression analysis considering sex, age, smoking provided an odds ratio 3.04 (95% 1.37, 6.75; 0.003). Hence, genotype, its especially high capacity, are significantly increased risk cancer.
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