Functional T cells in rabbits gut mucosal lymphocytes.

作者: D P Singal , M O'Neill , R Clancy , J Bienenstock

DOI: 10.1136/GUT.17.5.325

关键词: Lymphatic systemIntestinal mucosaLymphocyteIn vitroCellLamina propriaBiologyMolecular biologyFunctional studiesSpleenImmunologyGastroenterology

摘要: Functional studies of Peyer's patch and gut mucosa lymphocytes were performed in mixed lymphocyte culture reaction (MLC), an vitro measure the capacity T cells to recognize respond cell surface alloantigens. The data demonstrate functional effectiveness both these mucosal populations one-way MLC, as responding well stimulating cells. Both capacities MLC almost same observed for obtained from either spleen or thymus. We conclude that exist rabbit lamina propria patches with approximately quantitative MLC.

参考文章(15)
J. Bienenstock, R. L. Clancy, D. Y. E. Perey, O. Rudzik, D. P. Singal, The Distribution of a Rabbit Thymic Antigen and Membrane Immunoglobulins in Lymphoid Tissue, with Special Reference to Mucosal Lymphocytes Journal of Immunology. ,vol. 114, pp. 1- 4 ,(1975)
J. A. M. Kerckhaert, J. M. N. Willers, R. Benner, Cells involved in the graft-versus-host reaction in vitro. Immunology. ,vol. 25, pp. 103- 110 ,(1973)
R D Guttmann, D Y Perey, Peyer's patch cells. Absence of graft-versus-host reactivity in mice and rats. Laboratory Investigation. ,vol. 27, pp. 427- ,(1972)
Douglas M. Levin, Sharon M. Wahl, Herbert Y. Reynolds, David L. Rosenstreich, Peyer's Patch Lymphocytes: Demonstration of the Integrity of Afferent and Efferent T-Cell Functions in the Guinea Pig and Rat Journal of Immunology. ,vol. 113, pp. 1935- 1941 ,(1974)
Martin F. Kagnoff, Stephen Campbell, Functional characteristics of Peyer's patch lymphoid cells. I. Induction of humoral antibody and cell-mediated allograft reactions. Journal of Experimental Medicine. ,vol. 139, pp. 398- 406 ,(1974) , 10.1084/JEM.139.2.398
F. H. Bach, M. Segall, K. S. Zier, P. M. Sondel, B. J. Alter, M. L. Bach, Cell Mediated Immunity: Separation of Cells Involved in Recognitive and Destructive Phases Science. ,vol. 180, pp. 403- 406 ,(1973) , 10.1126/SCIENCE.180.4084.403
MARTIN C. RAFF, Theta isoantigen as a marker of thymus-derived lymphocytes in mice. Nature. ,vol. 224, pp. 378- 379 ,(1969) , 10.1038/224378A0
D. P. SlNGAL, E. V. YOUNGLAI, N. NAIPAUL, Inhibition of the Mixed Leucocyte Culture Reaction by Plasma from Renal Transplant Recipients Tissue Antigens. ,vol. 5, pp. 19- 25 ,(2008) , 10.1111/J.1399-0039.1975.TB00521.X