Lymphoid populations of gut mucosa in chickens

摘要: Alterations of the lymphoid populations within gut mucosa are commonly associated with humoral immunodeficiency diseases in man. Chickens provide a unique animal model for study abnormalities occurring immune deficiency states since agammaglobulinemia and selective immunoglobulin deficiencies can be induced this species. Two mucosal cells were obtained from small intestine chickens, using mechanical separation technique. One population was derived epithelium (intraepithelial lymphocytes), second lamina propria. Intraepithelial propria lymphocytes did not proliferate presence T or B mitogens as opposed to spleen; contained more surface Ig-bearing than spleen intraepithelial lymphocytes, reverse hemolytic plaque assay, but lymphocyte found rich immunoglobulin-secreting relative spleen. These preliminary studies demonstrated that these may insight into pathophysiology human gastrointestinal diseases.