CYCLOSPORIN IN THERAPEUTIC DOSES INCREASES RENAL ALLOGRAFT VASCULAR RESISTANCE
作者： JohnJ Curtis , Eva Dubovsky , JohnD Whelchel , RobertG Luke , ArnoldG Diethelm
DOI: 10.1016/S0140-6736(86)90355-7
关键词: Urology 、 Nephrotoxicity 、 Vascular resistance 、 Creatinine 、 Blood vessel 、 Renal blood flow 、 Transplantation 、 Endocrinology 、 Medicine 、 Internal medicine 、 Vasoconstriction 、 Kidney
摘要: In fourteen renal transplant patients converted from cyclosporin to azathioprine for financial reasons blood flow was greater and vascular resistance lower after conversion. These changes occurred without any change in serum creatinine. This finding suggests that the allograft vasoconstriction induced by occurs before evidence of nephrotoxicity is reversible. Renal recipients had cyclosporin-induced haemodynamic even early (2 weeks) transplantation, when still denervated. findings may explain increased sensitivity other nephrotoxic agents hypertension observed cyclosporin-treated patients.
sci-hub.se 参考文章(14)
D. A. Hunt, N. M. Jackson, M. D. White, H. D. Humes, R. P. O'Connor, Pathogenetic mechanisms of nephrotoxicity: insights into cyclosporine nephrotoxicity. Transplantation proceedings. ,vol. 17, pp. 51- 62 ,(1985)
P. H. Whiting, J. G. Simpson, R. J. Davidson, A. W. Thomson, Pathological changes in rats receiving cyclosporin A at immunotherapeutic dosage for 7 weeks. British journal of experimental pathology. ,vol. 64, pp. 437- 444 ,(1983)
E.V. Dubovsky, C.D. Russell, Quantitation of renal function with glomerular and tubular agents Seminars in Nuclear Medicine. ,vol. 12, pp. 308- 329 ,(1982) , 10.1016/S0001-2998(82)80013-5
JOHN F. GERKENS, S. B. Bhagwandeen, PETER J. DOSEN, ANTHONY J. SMITH, The effect of salt intake on cyclosporine-induced impairment of renal function in rats. Transplantation. ,vol. 38, pp. 412- 417 ,(1984) , 10.1097/00007890-198410000-00019
John P Bantle, Karl A Nath, David ER Sutherland, John S Najarian, Thomas F Ferris, Effects of Cyclosporine on the Renin-Angiotensin-Aldosterone System and Potassium Excretion in Renal Transplant Recipients Archives of Internal Medicine. ,vol. 145, pp. 505- 508 ,(1985) , 10.1001/ARCHINTE.1985.00360030153026
Venkateswara Rao, John T. Crosson, Carl M. Kjellstrand, Chronic irreversible nephrotoxicity from cyclosporin A Nephron. ,vol. 41, pp. 75- 77 ,(1985) , 10.1159/000183550
N. G. Moss, S. L. Powell, R. J. Falk, Intravenous cyclosporine activates afferent and efferent renal nerves and causes sodium retention in innervated kidneys in rats Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 8222- 8226 ,(1985) , 10.1073/PNAS.82.23.8222
J.R Chapman, N.G.L Harding, D Griffiths, P.J Morris, REVERSIBILITY OF CYCLOSPORIN NEPHROTOXICITY AFTER THREE MONTHS' TREATMENT The Lancet. ,vol. 325, pp. 128- 130 ,(1985) , 10.1016/S0140-6736(85)91902-6
A. F. Gazdar, G. J. Dammin, Neural Degeneration and Regeneration in Human Renal Transplants New England Journal of Medicine. ,vol. 283, pp. 222- 224 ,(1970) , 10.1056/NEJM197007302830502
Bryan D. Myers, Jon Ross, Lynn Newton, John Luetscher, Mark Perlroth, Cyclosporine-associated chronic nephropathy The New England Journal of Medicine. ,vol. 311, pp. 699- 705 ,(1984) , 10.1056/NEJM198409133111103