Azo polymers for colon-specific drug delivery. II: Influence of the type of azo polymer on the degradation by intestinal microflora
作者： G. Van den Mooter , C. Samyn , R. Kinget
DOI: 10.1016/0378-5173(93)90133-Z
关键词: Polymer 、 (Hydroxyethyl)methacrylate 、 Azobenzene 、 Permeability (electromagnetism) 、 Glycoside 、 Polymer chemistry 、 Drug delivery 、 Chemistry 、 Methyl methacrylate 、 Degradation (geology)
摘要: Abstract Degradation by gastrointestinal microflora of different azo polymers was studied performing permeability experiments on isolated films and solution viscosity measurements before after incubation in Schaedler broth, inoculated with human feces. The investigated were monomer composition (hydroxyethyl methacrylate/methyl methacrylate ratio) aromatic group (divinylazobenzene, N , ′-bis(methacryloylamino)azobenzene ′-bis(methacryloyloxyethyloxycarbony-lamino)azobenzene). degradation the strongly affected hydrophilicity polymers. chain length groups, built into polymers, seems to be little influence rate
elsevier.com
sci-hub.se 参考文章(11)
David R. Friend, Thomas N. Tozer, Drug glycosides in oral colon-specific drug delivery Journal of Controlled Release. ,vol. 19, pp. 109- 120 ,(1992) , 10.1016/0168-3659(92)90069-4
David R. Friend, George W. Chang, A colon-specific drug-delivery system based on drug glycosides and the glycosidases of colonic bacteria Journal of Medicinal Chemistry. ,vol. 27, pp. 261- 266 ,(1984) , 10.1021/JM00369A005
J. Kopeček, P. Kopečková, H. Brøndsted, R. Rathi, B. R̆íhová, P.-Y. Yeh, K. Ikesue, Polymers for colon-specific drug delivery Journal of Controlled Release. ,vol. 19, pp. 121- 130 ,(1992) , 10.1016/0168-3659(92)90070-8
Ulrich Klotz, Clinical pharmacokinetics of sulphasalazine, its metabolites and other prodrugs of 5-aminosalicylic acid. Clinical Pharmacokinectics. ,vol. 10, pp. 285- 302 ,(1985) , 10.2165/00003088-198510040-00001
H BRONDSTED, J KOPECEK, Hydrogels for site-specific oral drug delivery: synthesis and characterization. Biomaterials. ,vol. 12, pp. 584- 592 ,(1991) , 10.1016/0142-9612(91)90056-G
M Saffran, G. Kumar, C Savariar, J. Burnham, F Williams, D. Neckers, A new approach to the oral administration of insulin and other peptide drugs Science. ,vol. 233, pp. 1081- 1084 ,(1986) , 10.1126/SCIENCE.3526553
G. Sudesh Kumar, C. Savariar, M. Saffran, D. C. Neckers, Chelating copolymers containing photosensitive functionalities. 3. Photochromism of cross-linked polymers Macromolecules. ,vol. 18, pp. 1525- 1530 ,(1985) , 10.1021/MA00150A002
G. Van den Mooter, C. Samyn, R. Kinget, Azo polymers for colon-specific drug delivery International Journal of Pharmaceutics. ,vol. 87, pp. 37- 46 ,(1992) , 10.1016/0378-5173(92)90225-Q
David R. Friend, George W. Chang, Drug glycosides: potential prodrugs for colon-specific drug delivery Journal of Medicinal Chemistry. ,vol. 28, pp. 51- 57 ,(1985) , 10.1021/JM00379A012
Mark A. Peppercorn, Peter Goldman, THE ROLE OF INTESTINAL BACTERIA IN THE METABOLISM OF SALICYLAZOSULFAPYRIDINE Journal of Pharmacology and Experimental Therapeutics. ,vol. 181, pp. 555- 562 ,(1972)