Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude

摘要: Drug delivery by nanocarriers (NCs) has long been stymied dominant liver uptake and limited target organ deposition, even when NCs are targeted using affinity moieties. Here we report a universal solution: red blood cell (RBC)-hitchhiking (RH), in which adsorbed onto the RBCs transfer from to first downstream of intravascular injection. RH improves for wide range viral vectors. For example, injected intravenously increases liposome organ, lungs, ~40-fold compared with free NCs. Intra-carotid artery injection delivers >10% NC dose brain, ~10× higher than that achieved Further, works mice, pigs, ex vivo human lungs without causing RBC or end-organ toxicities. Thus, is clinically translatable platform technology poised augment drug acute lung disease, stroke, several other diseases.