Natural product toosendanin reverses the resistance of human breast cancer cells to adriamycin as a novel PI3K inhibitor.
作者： Wang Kai , Shan Yating , Ma Lin , Yang Kaiyong , Hua Baojin
DOI: 10.1016/J.BCP.2018.03.022
关键词: Cancer cell 、 Multiple drug resistance 、 Drug 、 Cancer research 、 P110α 、 Chemistry 、 Immunofluorescence 、 Breast cancer 、 Downregulation and upregulation 、 PI3K/AKT/mTOR pathway
摘要: … In this study, we found for the first time that toosendanin (TSN), a triterpenoid extracted from the traditional Chinese medicine Melia toosendan Sieb et Zucc, could successfully reverse …
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