AGMATINE : A NOVEL NEUROTRANSMITTER ?

摘要: Publisher Summary Current evidence is consistent with a hypothesis that agmatine meets many criteria for neurotransmitter-neuromodulator. It synthesized, stored, and released in brain; contained neurons axon terminals heterogeneous distribution; interacts cell-specific receptors; elicits biological actions within the central nervous system. Immunocytochemically, has been localized brain adrenal using polyclonal antibodies. While untreated agmatine-like immunoreactivity (-LI) detected only few perikarya, after pretreatment intracerebroventricular (i.c.v.) colchicine, it can be seen cytoplasm of throughout brain. These are most heavily concentrated hypothalamus, neocortex, periaquaductal regions midbrain. By electron microscopy agmatine-LI dense-core vesicles nucleus tractus solatarii hilus hippocampal formation. Hence, its storage site such would expected neurotransmitter candidate. Agmatine binds high affinity to α2-adrenergic receptors all subclasses imidazoline I1 I2 subclasses. The fact amines present IRs raised question whether might, like other bioamines, have own right, possibly as