Spectral parameters modulation and source localization of blink-related alpha and low-beta oscillations differentiate minimally conscious state from vegetative state/unresponsive wakefulness syndrome
作者： Luca Bonfiglio , Andrea Piarulli , Umberto Olcese , Paolo Andre , Pieranna Arrighi
DOI: 10.1371/JOURNAL.PONE.0093252
关键词: Task-positive network 、 Bioinformatics 、 Cardiology 、 Internal medicine 、 Posterior cingulate 、 Electroencephalography 、 Beta Rhythm 、 Persistent vegetative state 、 Medicine 、 Wakefulness 、 Precuneus 、 Minimally conscious state
摘要: Recently, the cortical source of blink-related delta oscillations (delta BROs) in resting healthy subjects has been localized posterior cingulate cortex/precuneus (PCC/PCu), one main core-hubs default-mode network. This interpreted as electrophysiological signature automatic monitoring surrounding environment while are immersed self-reflecting mental activities. Although BROs were directly correlated to degree consciousness impairment patients with disorders consciousness, they failed differentiate vegetative state/unresponsive wakefulness syndrome (VS/UWS) from minimally conscious state (MCS). In present study, we have extended analysis frequency bands other than attempt find a biological marker that could support differential diagnosis between VS/UWS and MCS. Four VS/UWS, 5 MCS, 12 matched controls (CTRL) underwent standard 19-channels EEG recordings during conditions. Three-second-lasting epochs centred on each blink instance submitted time-frequency analyses order extract normalized Blink-Related Synchronization/Desynchronization (nBRS/BRD) three interest (low-alpha, high-alpha low-beta) time-window 50–550 ms after blink-peak estimate corresponding sources electrical activity. nBRS/BRD levels all lower those related both CTRL thus enabling MCS VS/UWS. Furthermore, showed an intermediate signal intensity PCC/PCu higher left temporo-parieto-occipital junction inferior occipito-temporal regions when compared peculiar pattern activation leads us hypothesize bottom-up driven task positive network tendentially prone respond environmental stimuli, even though almost unintentional way.
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