Time-varying moderation of treatment outcomes by illness duration and comorbid depression in generalized anxiety disorder.

摘要: Objective To extend the sparse literature on moderators, we used time-varying effect modeling (TVEM; Tan, Shiyko, Li, & Dierker, 2012) to examine how depressive symptoms and duration of generalized anxiety disorder (GAD) moderated effects 3 treatments for GAD (applied relaxation [AR], cognitive-behavioral therapy [CBT], nondirective [ND]) over time using intensive repeated measures. Method In a secondary analysis Borkovec Costello (1993), 66 clients were randomly assigned AR (n = 23), CBT or ND 20). Clients received 12 sessions 6 weeks, after 2 weeks posttreatment assessment, had additional weekly fading sessions. They completed thrice daily ratings during this 10-week period. (Anxiety Disorders Interview Schedule-Revised) (Hamilton Depression Rating Scale) assessed at baseline. Results Longer predicted less reduction in relative AR. These pronounced later phase treatment, suggesting benefits focused practice with longer duration. Higher depression better response than ND. The moderation also more noticeable phase. multilevel analyses, similar pattern held 1-year follow-up clinician-rated Conclusion long-standing may benefit from repeatedly practicing fewer skills learning multiple skills. On other hand, comorbid respond AR, perhaps because includes cognitive interventions that can generalize depression. (PsycINFO Database Record (c) 2019 APA, all rights reserved).