Broad inter‐individual variations in circulating progenitor cell numbers induced by granulocyte colony‐stimulating factor therapy
作者： A. W. Roberts , E. DeLuca , D. Metcalf , C. G. Begley , R. Basser
关键词: Biology 、 Progenitor cell 、 Granulocyte 、 Transplantation 、 Andrology 、 Cancer 、 Circulating Progenitor Cell 、 Granulocyte colony-stimulating factor 、 Myeloid 、 Immunology 、 Radiation therapy
摘要: The elevated white cell counts (WCC) and myeloid progenitor levels in the blood induced by granulocyte colony-stimulating factor (G-CSF) treatment were studied three settings: cancer patients previously treated with chemo/radiotherapy (n = 13), untreated 5) normal volunteers 9). inter-individual variations mobilization responses to G-CSF impact of previous investigated. absolute circulating cells, but not total reduced significantly pretreated (median 961, range 289-3355 per ml blood) as compared 9891, 2219-16625 blood). In each setting, wide ranges numbers observed, variation was considerably greater than observed for WCC. However, (942-25296 demonstrated much variance patients. This broad physiological needs be considered when designing strategies allogeneic peripheral stem transplantation.
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