Multifunctional Role of Astrocyte Elevated Gene-1 (AEG-1) in Cancer: Focus on Drug Resistance.

摘要: Cancer development results from the acquisition of numerous genetic and epigenetic alterations in cancer cells themselves, as well continuous changes their microenvironment. The plasticity allows them to continuously adapt selective pressures brought forth by exogenous environmental stresses, internal milieu tumor treatment itself. Resistance treatment, either inherent or acquired after commencement is a major obstacle an oncologist confronts endeavor efficiently manage disease. chemotherapy, chemoresistance, important hallmark aggressive cancers, driver oncogene-induced signaling pathways molecular abnormalities create platform for chemoresistance. oncogene Astrocyte elevated gene-1/Metadherin (AEG-1/MTDH) overexpressed diverse array its overexpression promotes all hallmarks cancer, such proliferation, invasion, metastasis, angiogenesis present review provides comprehensive description mechanism which AEG-1 tumorigenesis, with special emphasis on ability regulate