Antiallergic agents from natural sources 9. Inhibition of nitric oxide production by novel chalcone derivatives from Mallotus philippinensis (Euphorbiaceae).
作者： Akihiro Daikonya , Shigeki Katsuki , Susumu Kitanaka
DOI: 10.1248/CPB.52.1326
关键词: Nitric oxide 、 Gene expression 、 Lipopolysaccharide 、 Chemistry 、 Antiallergic agent 、 Biochemistry 、 Euphorbiaceae 、 Recombinant DNA 、 Chalcone 、 Cell culture
摘要: Three novel chalcone derivatives, mallotophilippens C (1), D (2) and E (3) were isolated from the fruits of Mallotus philippinensis MUELL. ARG. These compounds identified, using chemical spectral data, as 1-[6-(3,7-dimethyl-octa-2,6-dienyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-3-(4-hydroxy-phenyl)-propenone, 3-(3,4-dihydroxy-phenyl)-1-[6-(3,7-dimethyl-octa-2,6-dienyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl]-propenone 1-[5,7-dihydroxy-2-methyl-6-(3-methyl-but-2-enyl)-2-(4-methyl-pent-3-enyl)-2H-chromen-8-yl]-3-(3,4-dihydroxy-phenyl)-propenone, respectively. They inhibited nitric oxide (NO) production inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated lipopolysaccharide (LPS) recombinant mouse interferon-gamma (IFN-gamma). Furthermore, they downregulated cyclooxygenase-2 (COX-2) gene, interleukin-6 (IL-6) interleukin-1beta (IL-1beta) expression. results suggest that have anti-inflammatory immunoregulatory effects.
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