Quercetin: Further investigation of its antinociceptive properties and mechanisms of action

摘要: The antinociceptive action of quercetin, a common bioactive flavonoid present in many medicinal plants, was assessed different models chemical and thermal nociception mice. Quercetin (10-60 mg/kg, i.p. or 100-500 p.o.) dose-dependently inhibited nociceptive behavior the acetic acid-induced pain test. Moreover, quercetin i.p.) both phases formalin-induced pain, with ID50 values 374.1 (68.0-402.0) mmol/kg 103.0 (45.0-201.0) mmol/kg, for neurogenic inflammatory phases, respectively. mg/kg) also induced by glutamate capsaicin 68.2% 75.5%, Its analgesic significantly reversed p-chlorophenylalanine methyl ester, katanserin, methysergide, GABA(A) antagonist (bicuculline), GABA(B) antagonists (baclofen). modulated tachykinins, but not affected adrenal-gland hormones. Furthermore, effects did result from muscle-relaxant sedative action. Together, these results indicate that produces dose-related anti-nociception several through mechanisms involve interaction L-arginine-nitric oxide, serotonin, GABAergic systems. These confirm extend other investigations on effect its