Cytoskeletal Focal Adhesion Proteins Fascin-1 and Paxillin Are Predictors of Malignant Progression and Poor Prognosis in Human Breast Cancer

摘要: Breast cancer is a major health problem in both developing and developed countries. The incremental motility of malignant cells critical step their migration, invasion, metastasis regulated by the reorganization actin cytoskeleton regulation focal adhesion. Fascin-1 paxillin are essential components these cellular structures. In cancer, expression level fascin-1 can vary depending on cell type. However, its precise role breast Saudi women has not been evaluated any published study. We investigated carcinoma, we have related results to established prognostic factors. studied 100 carcinoma specimens. Immunohistochemical analyses for were conducted paraffin sections tissues using avidin-biotin peroxidase method. expressed 58% 43% infiltrating duct (IDC) cases. There was statistically significant correlation between with each following: tumor grade, clinical stage, lymph-node HER2 expression. Furthermore, there immunostaining but no such association PR or ER status. Increased IDC poor factors support strong progression, human indicating that markers be used as target development novel therapies.