Helicobacter pylori phase variation, immune modulation and gastric autoimmunity
作者： Mathijs Bergman , Gianfranco Del Prete , Yvette van Kooyk , Ben Appelmelk
DOI: 10.1038/NRMICRO1344
关键词: Helicobacter pylori 、 Phase variation 、 Immunology 、 Autoimmunity 、 Host (biology) 、 Pathogen 、 Antigen 、 Colonization 、 Immune modulation 、 Microbiology 、 Biology
摘要: Helicobacter pylori can be regarded as a model pathogen for studying persistent colonization of humans. Phase-variable expression Lewis blood-group antigens by H. allows this microorganism to modulate the host T-helper-1-cell versus T-helper-2-cell response. We describe in which interactions between lectins and carbohydrates facilitate asymptomatic persistence pylori. This delicate balance, favourable both host, could lead gastric autoimmunity genetically susceptible individuals.
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M Stolte, A Meining, E Meier, Cure of autoimmune gastritis by Helicobacter pylori eradication in a 21-year-old male. Zeitschrift Fur Gastroenterologie. ,vol. 36, pp. 641- 643 ,(1998)
K Baumann, M Stolte, M Ritter, H Eidt, E Lauer, B Bethke, Active autoimmune gastritis without total atrophy of the glands. Zeitschrift Fur Gastroenterologie. ,vol. 30, pp. 729- 735 ,(1992)
W.E. Karnes, I.M. Samloff, M. Siurala, M. Kekki, P. Sipponen, S.W.R. Kim, J.H. Walsh, Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis Gastroenterology. ,vol. 101, pp. 167- 174 ,(1991) , 10.1016/0016-5085(91)90474-Y
D Burroni, G Del Prete, M M D'Elios, S Romagnani, M De Carli, C T Baldari, M Manghetti, J L Telford, F Costa, T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease. Journal of Immunology. ,vol. 158, pp. 962- 967 ,(1997)
Ben J. Appelmelk, Irma van Die, Sandra J. van Vliet, Christina M. J. E. Vandenbroucke-Grauls, Teunis B. H. Geijtenbeek, Yvette van Kooyk, Cutting Edge: Carbohydrate Profiling Identifies New Pathogens That Interact with Dendritic Cell-Specific ICAM-3-Grabbing Nonintegrin on Dendritic Cells The Journal of Immunology. ,vol. 170, pp. 1635- 1639 ,(2003) , 10.4049/JIMMUNOL.170.4.1635
D TAYLOR, D RASKO, R SHERBURNE, C HO, L JEWELL, Lack of correlation between Lewis antigen expression by Helicobacter pylori and gastric epithelial cells in infected patients Gastroenterology. ,vol. 115, pp. 1113- 1122 ,(1998) , 10.1016/S0016-5085(98)70082-4
Philipp M. Lepper, Martha Triantafilou, Christian Schumann, E. Marion Schneider, Kathy Triantafilou, Lipopolysaccharides from Helicobacter pylori can act as antagonists for Toll-like receptor 4. Cellular Microbiology. ,vol. 7, pp. 519- 528 ,(2005) , 10.1111/J.1462-5822.2005.00482.X
Lesley E. Smythies, Ken B. Waites, J. Russell Lindsey, Paul R. Harris, Paolo Ghiara, Phillip D. Smith, Helicobacter pylori-Induced Mucosal Inflammation Is Th1 Mediated and Exacerbated in IL-4, But Not IFN-γ, Gene-Deficient Mice The Journal of Immunology. ,vol. 165, pp. 1022- 1029 ,(2000) , 10.4049/JIMMUNOL.165.2.1022
J ALEXANDER, K BRYSON, T helper (h)1/Th2 and Leishmania: paradox rather than paradigm. Immunology Letters. ,vol. 99, pp. 17- 23 ,(2005) , 10.1016/J.IMLET.2005.01.009
Ge Wang, Zhongming Ge, David A. Rasko, Diane E. Taylor, Lewis antigens in Helicobacter pylori: biosynthesis and phase variation. Molecular Microbiology. ,vol. 36, pp. 1187- 1196 ,(2002) , 10.1046/J.1365-2958.2000.01934.X