Cure of autoimmune gastritis by Helicobacter pylori eradication in a 21-year-old male.

摘要: Background More recent investigations have shown that in some patients Helicobacter pylori (Hp) antibodies can act as antigastric and lead to atrophic autoimmune gastritis of the oxyntic mucosa. The question thus arises whether this form be healed by eradicating Hp. Methods Case history a 21-year-old man with active mucosa lymphocytic infiltration entire lamina propria, foci destruction number glands, hypertrophy preserved parietal cells, but no signs Hp Warthin Starry stain. search for cell intrinsic factor proved negative, while level gastrin serum was slightly elevated. Since presence IgG (243 U/ml) confirmed. eradication therapy carried out. Results 15 months after treatment antibody titre had decreased 11 U/ml. healed, autoaggressive inflammatory infiltrates focal corpus glands cells were longer detectable. Conclusions Autoimmune induced may possibly cured treatment; confirm this, further controlled prospective studies are needed.