25 Years of research on global asphyxia in the immature rat brain

摘要: Hypoxic-ischemic encephalopathy remains a common cause of brain damage in neonates. Preterm infants have additional complications, as prematurity by itself increases the risk encephalopathy. Currently, therapy for this subset asphyxiated is limited to supportive care. There an urgent need therapies preterm - and representative animal models preclinical drug development. In 1991, novel rodent model global asphyxia infant was developed Sweden. This method based on induction during birth processes submerging pups, still uterine horns, water bath followed C-section. insult occurs at time-point when maturity resembles 22-32 week old human fetus. has over past 25 years established perinatal early brain. Here we summarize knowledge gained short- long-term neuropathological behavioral effects immature central nervous system.