Moderate and severe perinatal asphyxia induces differential effects on cocaine sensitization in adult rats

摘要: Perinatal asphyxia (PA) increases the likelihood of suffering from dopamine-related disorders, such as ADHD and schizophrenia. Since dopaminergic transmission plays a major role in cocaine sensitization, purpose this study was to determine whether PA could be associated with altered behavioral sensitization cocaine. To end, adult rats born vaginally (CTL), by caesarean section (C+), or C+ 15 min (PA15, moderate PA) 19 (PA19, severe global anoxia were repeatedly administered (i.p., mg/kg) then challenged after 5-day withdrawal period. In addition, c-Fos, FosB/FosB, DAT, TH expression assessed dorsal (CPu) ventral (NAcc) striatum. Results indicated that PA15 exhibited an increased locomotor cocaine, while PA19 displayed abnormal acquisition did not express sensitized response c-Fos NAcc, but CPu, these alterations sensitization. FosB/FosB all groups regions repeated administration, although it reached lower levels rats. CTL, C+, PA15, rats, NAcc reduced treated independently challenge test. Furthermore, reduction more pronounced DAT remained unaltered studied. These results suggest may increase vulnerability drug abuse particular addiction.