Effects of GABA-ergic agents on spontaneous non-convulsive epilepsy, EEG and behaviour, in the WAG/Rij inbred strain of rats
作者： BWMM Peeters , CM Van Rijn , JMH Vossen , AML Coenen , None
DOI: 10.1016/0024-3205(89)90505-5
关键词: Epilepsy 、 Muscimol 、 Bicuculline 、 GABAergic 、 Electroencephalography 、 Neuroscience 、 Inbred strain 、 Endocrinology 、 Internal medicine 、 GABAA receptor 、 Medicine 、 Animal model
摘要: The effects of GABAergic agents on non-convulsive epilepsy were studied by intracerebroventricular injections muscimol and bicuculline in WAG/Rij rats. rat strain is recognized as an animal model for human absence epilepsy. EEG registrations behavioural observations showed that dose-dependently increased the Besides this, it induced spikes body twitches. Bicuculline twitches well but decreased All can be blocked vice versa, which suggests observed are genuine GABAA effects. These results implicate caused a hyperfunction.
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sci-hub.se 参考文章(13)
Richard W. Olsen, The GABA postsynaptic membrane receptor-ionophore complex Molecular and Cellular Biochemistry. ,vol. 39, pp. 261- 279 ,(1981) , 10.1007/978-94-009-8027-3_17
W.D. Matthews, G.P. McCafferty, Anticonvulsant activity of muscimol against seizures induced by impairment of GABA-mediated neurotransmission. Neuropharmacology. ,vol. 18, pp. 885- 889 ,(1979) , 10.1016/0028-3908(79)90086-8
Wolfgang Löscher, Hartmut Siemes, Cerebrospinal fluid gamma-aminobutyric acid levels in children with different types of epilepsy: effect of anticonvulsant treatment. Epilepsia. ,vol. 26, pp. 314- 319 ,(1985) , 10.1111/J.1528-1157.1985.TB05656.X
J. H. Wood, T. A. Hare, B. S. Glaeser, J. C. Ballenger, R. M. Post, Low cerebrospinal fluid γ‐aminobutyric acid content in seizure patients Neurology. ,vol. 29, pp. 1203- 1203 ,(1979) , 10.1212/WNL.29.9_PART_1.1203
T. A. Pedley, R. W. Horton, B. S. Meldrum, Electroencephalographic and behavioral effects of a GABA agonist (muscimol) on photosensitive epilepsy in the baboon, papio papio. Epilepsia. ,vol. 20, pp. 409- 416 ,(1979) , 10.1111/J.1528-1157.1979.TB04821.X
A.P. Kent, R.A. Webster, The role of GABA and excitatory amino acids in the development of the leptazol-induced epileptogenic EEG. Neuropharmacology. ,vol. 25, pp. 1023- 1030 ,(1986) , 10.1016/0028-3908(86)90197-8
G KING, Effects of systemically applied GABA agonists and antagonists on wave-spike ECoG activity in rat. Neuropharmacology. ,vol. 18, pp. 47- 55 ,(1979) , 10.1016/0028-3908(79)90008-X
E.L.J.M. van Luijtelaar, A.M.L. Coenen, Two types of electrocortical paroxysms in an inbred strain of rats Neuroscience Letters. ,vol. 70, pp. 393- 397 ,(1986) , 10.1016/0304-3940(86)90586-0
A. Scotti De Carolis, F. Lipparini, V. G. Longo, Neuropharmacological investigations on muscimol, a psychotropic drug extracted from Amanita muscaria. Psychopharmacology. ,vol. 15, pp. 186- 195 ,(1969) , 10.1007/BF00411168
M. Vergens, C. Marescaux, G. Micheletti, A. Depaulis, L. Rumbach, J.M. Warter, Enhancement of spike and wave discharges by GABAmimetic drugs in rats with spontaneous petit-mallike epilepsy Neuroscience Letters. ,vol. 44, pp. 91- 94 ,(1984) , 10.1016/0304-3940(84)90226-X