Electroencephalographic and behavioral effects of a GABA agonist (muscimol) on photosensitive epilepsy in the baboon, papio papio.
作者： T. A. Pedley , R. W. Horton , B. S. Meldrum
DOI: 10.1111/J.1528-1157.1979.TB04821.X
关键词: Spike wave 、 Muscimol 、 Baboon 、 Photosensitive epilepsy 、 Endocrinology 、 Anesthesia 、 Agonist 、 Internal medicine 、 LIGHT STIMULATION 、 Chemistry
摘要: Summary: Muscimol, 0.25-1.0 mg/kg, i.v., was administered acutely to 4 adolescent baboons, Papio papio, that show photically induced epilepsy. On the EEG, slowing of background rhythms associated with appearance spikes, polyspikes, and recurring symmetrical spike-wave complexes. These changes were maximal 0.5-2 hr after muscimol injection. Regular testing intermittent light stimulation showed either no change from control responses or a more severe epileptiform EEG 0.1–3 muscimol. Photically myoclonus not modified by Despite its GABA-agonist properties, is an effective anticonvulsant. RESUME Une injection i.v. de (0.25-1.0 mg/kg) ete administeree quatre babouins adolescents, presentant une epilepsie photosensible. observe modification ĽEEG, atteignant son maximum 0.5 2 heures apres Ľ muscimol, caracterisee par un ralentissement des rythmes fond et la survenue pointes, polypointes complexes pointe-ondes symetriques recurrents. La lumineuse intermittente fournissait meme reponse qu'avant ou exageree. Les myoclonies provoquees S.L.I, n‘etaient pas non plus modifyees. Malgre ses proprietes “GABA-agonistes” le n'est done anticonvulsivant efficace. RESUMEN A cuatro mandriles, adolescentes que mostraban epilepsyia inducida foticamente se les inyectaron, intravenosamente, 0.25 1.0 mg/kg En el una lentificacion los ritmos fondo, asocio aparicion puntas, polipuntas y complejos punta-onda simetricos recurrentes. Estas alteraciones alcanzaron su representacion maxima entre las haber inyectado Estudios regulares con estimulacion luminosa intermitente, o mostraron cambios respues-tas control, mayor severidad epileptiforme 0.1 3 tras inyeccion Las mioclonias inducidas modificaron A pesar sus pro-piedades agonista del GABA, es anticonvulsivante eficaz. ZUSAMMENFASSUNG 0.25 bis 1.00 KG Muscimol wurde intravenos akut adoleszenten papios mit fotosensibler Epilepsie gegeben. Im war eine Verlangsamung der Grundaktivitat verknupft dem Auftreten von poly-spikes und wiederholten symmetrischen spike wave Komplexen. Diese Veranderungen zeigten ein Maximum Stunden nach Muscimol-Injektion. Die routine-masige Untersuchung in-termittierender Lichtreizung zeigte entweder keine Anderung gegenuber Kontrollantworten oder schwerere EEG-Aktivitat Muscimol. Der fotosensible Myoklonus nicht durch modifiziert. Trotz seiner GABA-ahnlichen Eigenschaften ist kein wirksames Antikonvulsivum.
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