Sex-Specific Association between Longitudinal Changes in Adiposity, FTO rs9939609 Polymorphism, and Leukocyte Telomere Length
作者： Chol Shin , Nan Hee Kim , Inkyung Baik
DOI: 10.1080/07315724.2015.1005197
关键词: Cohort 、 Waist 、 Alpha-Ketoglutarate-Dependent Dioxygenase FTO 、 Body mass index 、 Prospective cohort study 、 Biology 、 Endocrinology 、 Population 、 Longitudinal study 、 Internal medicine 、 Polymorphism (computer science)
摘要: Objective: A longitudinal study was conducted to examine sex-specific associations between changes in adiposity over a 10-year period, the FTO rs9939609 polymorphism, and leukocyte telomere length (LTL).Methods: population-based cohort including 2128 middle-aged older Korean men (n = 1087) women 1041) participated prospective study. Anthropometric measurements of weight, height, waist hip circumference were taken at baseline (from 2001 2003) follow-up period 2011 2012). The polymorphism genotyped using DNA samples collected LTL assessed period. Multiple linear regression analysis used with adjustments for age, body mass index, other potential confounders.Results: Presence risk allele inversely associated (p < 0.01) all participants, significant association seen only when genders modeled separate...
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