FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth

摘要: Genome-wide association studies found common variants in the fat mass and obesity-associated (FTO) gene associated with adiposity Caucasians Asians but was not confirmed African populations. Association of FTO insulin resistance energy intake showed inconsistent results previous studies. This study aimed to assess influence variant rs9939609 on adiposity, resistance, physical activity European - (EA) African-American (AA) youth. We conducted a cross-sectional EA AA youths. One thousand, nine hundred seventy-eight youths (48.2% EAs, 47.1% male, mean age 16.5 years) had measures anthropometry. Percent body (%BF) measured by dual-energy X-ray absorptiometry, visceral adipose tissue (VAT) subcutaneous abdominal (SAAT) magnetic resonance imaging. Energy were based self report from up 7 24-hour recalls. Physical also accelerometry. FTO significantly index (BMI) (P = 0.01), weight 0.03) waist circumference 0.04), per-allele effects 0.4 kg/m2, 1.3 kg 0.8 cm, respectively. No significant between %BF, VAT, SAAT or > 0.05), vigorous 0.05). interactions ethnicity, gender, observed The is modestly BMI circumference, activity. Moreover, these similar for EAs AAs. Improved understanding effect will offer new insights into etiology excess adiposity.