Studies of the thymus in mice bearing the Lewis lung carcinoma
作者： Dominique Kaiserlian , Wilson Savino , Jean-François Bach
DOI: 10.1016/0008-8749(83)90105-3
关键词: Primary tumor 、 Lewis lung carcinoma 、 Natural killer cell 、 Lymphokine-activated killer cell 、 Spleen 、 Pathology 、 Biology 、 Cytotoxicity 、 Cortex (anatomy) 、 Metastasis 、 Immunology
摘要: Natural killer (NK) cell activity of spleen and thymus was studied in Lewis lung carcinoma (3LL)-bearing mice. A high level hydrocortisone-sensitive NK cytotoxicity found the after excision primary tumor, but not nonamputated Conversely, splenic diminished tumor-bearing mice remained unmodified amputated Excision tumor prevented tumor-induced thymic atrophy splenomegaly. Histological study revealed presence metastatic cells within cortex. These data suggest that or their precursors are present can be triggered unmasked situ by migrating from tumor.
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