Effects of sera from tumor-bearing mice on mitogen and allogeneic cell stimulation of normal lymphoid cells.

摘要: The mitogens concanavalin A (Con A) and bacterial lipopolysaccharide (LPS) stimulated normal spleen cells of DBA/2J, CBA/J, BALB/c mice about equally in the presence either isologous or homologous serum. This system revealed that sera from with five different methylcholanthrene-induced rhabdomyosarcomas inhibited mitogen stimulation cells. Sera a mammaryadenocarcinoma spontaneous rhabdomyosarcoma were similarly suppressive. In contrast, melanoma not inhibitory often enhanced stimulation. tumor-bearing animals had same effects both qualitatively quantitatively on strain carrying tumor other two strains. mixed lymphocyte response CBA/J times was affected exactly as responses to by various sera. Stimulation mouse lymph-node macrophages removed, well guinea pig cells, also mammary adenocarcinoma.