Molecular Dimensions of Gastric Cancer: Translational and Clinical Perspectives.
作者： Yoon Young Choi , Sung Hoon Noh , Jae-Ho Cheong
关键词: Molecular classification 、 Medicine 、 Chromosome instability 、 Disease 、 Molecular dimensions 、 Clinical trial 、 Bioinformatics 、 Global health 、 Precision medicine 、 Functional validation
摘要: Gastric cancer is a global health burden and has the highest incidence in East Asia. This disease complex nature because it arises from multiple interactions of genetic, local environmental, host factors, resulting biological heterogeneity. genetic intricacy converges on molecular characteristics reflecting pathophysiology, tumor biology, clinical outcome. Therefore, understanding at genomic level pivotal to improving care patients with gastric cancer. A recent landmark study, The Cancer Genome Atlas (TCGA) project, showed landscape through comprehensive evaluation 295 primary cancers. proposed classification divided into four subtypes: Epstein-Barr virus-positive, microsatellite unstable, stable, chromosomal instability. information will be taken account future trials translated therapeutic decisions. To fully realize benefit, many challenges must overcome. Rapid growth high-throughput biology functional validation targets further deepen our knowledge dimensions this cancer, allowing for personalized precision medicine.
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sci-hub.st 参考文章(85)
Igor Puzanov, Ravi K. Amaravadi, Grant A. McArthur, Keith T. Flaherty, Paul B. Chapman, Jeffrey A. Sosman, Antoni Ribas, Mark Shackleton, Patrick Hwu, Bartosz Chmielowski, Keith B. Nolop, Paul S. Lin, Kevin B. Kim, Long-term outcome in BRAFV600E melanoma patients treated with vemurafenib: Patterns of disease progression and clinical management of limited progression European Journal of Cancer. ,vol. 51, pp. 1435- 1443 ,(2015) , 10.1016/J.EJCA.2015.04.010
Roopma Wadhwa, Shumei Song, Ju-Seog Lee, Yixin Yao, Qingyi Wei, Jaffer A. Ajani, Gastric cancer—molecular and clinical dimensions Nature Reviews Clinical Oncology. ,vol. 10, pp. 643- 655 ,(2013) , 10.1038/NRCLINONC.2013.170
Fred T Bosman, Fatima Carneiro, Ralph H Hruban, Neil D Theise, WHO Classification of Tumours of the Digestive System WHO classification of tumours of the digestive system.. ,(2010)
Fei Yao, Jaya P Kausalya, Yee Yen Sia, Audrey SM Teo, Wah Heng Lee, Alicia GM Ong, Zhenshui Zhang, Joanna HJ Tan, Guoliang Li, Denis Bertrand, Xingliang Liu, Huay Mei Poh, Peiyong Guan, Feng Zhu, Thushangi Nadeera Pathiraja, Pramila N Ariyaratne, Jaideepraj Rao, Xing Yi Woo, Shaojiang Cai, Fabianus H Mulawadi, Wan Ting Poh, Lavanya Veeravalli, Chee Seng Chan, Seong Soo Lim, See Ting Leong, Say Chuan Neo, Poh Sum D Choi, Elaine GY Chew, Niranjan Nagarajan, Pierre-Etienne Jacques, Jimmy BY So, Xiaoan Ruan, Khay Guan Yeoh, Patrick Tan, Wing-Kin Sung, Walter Hunziker, Yijun Ruan, Axel M Hillmer, Recurrent Fusion Genes in Gastric Cancer: CLDN18-ARHGAP26 Induces Loss of Epithelial Integrity Cell Reports. ,vol. 12, pp. 272- 285 ,(2015) , 10.1016/J.CELREP.2015.06.020
Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. ,vol. 136, ,(2015) , 10.1002/IJC.29210
Yoon Young Choi, Jung Min Bae, Ji Yeong An, In Gyu Kwon, In Cho, Hyun Beak Shin, Tanaka Eiji, Mohammad Aburahmah, Hyung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh, Is microsatellite instability a prognostic marker in gastric cancer?: A systematic review with meta‐analysis Journal of Surgical Oncology. ,vol. 110, pp. 129- 135 ,(2014) , 10.1002/JSO.23618
Soo Young Kim, Yoon Young Choi, Ji Yeong An, Hyun Beak Shin, Ara Jo, Hyeji Choi, Sang Hyuk Seo, Hui-Jae Bang, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh, The benefit of microsatellite instability is attenuated by chemotherapy in stage II and stage III gastric cancer: Results from a large cohort with subgroup analyses International Journal of Cancer. ,vol. 137, pp. 819- 825 ,(2015) , 10.1002/IJC.29449
Feriyl Bhaijee, Thomas Huebner, Ralph H. Hruban, Laura D. Wood, Nathan Cuka, Drew M. Pardoll, Nickolas Papadopoulos, Kenneth W. Kinzler, Shibin Zhou, Toby C. Cornish, Janis M. Taube, Robert A. Anders, James R. Eshleman, Bert Vogelstein, Luis A. Diaz, Dung T. Le, Jennifer N. Uram, Hao Wang, Bjarne R. Bartlett, Holly Kemberling, Aleksandra D. Eyring, Andrew D. Skora, Brandon S. Luber, Nilofer S. Azad, Dan Laheru, Barbara Biedrzycki, Ross C. Donehower, Atif Zaheer, George A. Fisher, Todd S. Crocenzi, James J. Lee, Steven M. Duffy, Richard M. Goldberg, Albert de la Chapelle, Minori Koshiji, PD-1 Blockade in Tumors with Mismatch-Repair Deficiency The New England Journal of Medicine. ,vol. 372, pp. 2509- 2520 ,(2015) , 10.1056/NEJMOA1500596
Yoon Young Choi, Sung Hoon Noh, Jae-Ho Cheong, Evolution of Gastric Cancer Treatment: From the Golden Age of Surgery to an Era of Precision Medicine. Yonsei Medical Journal. ,vol. 56, pp. 1177- 1185 ,(2015) , 10.3349/YMJ.2015.56.5.1177
Patrick Tan, Khay-Guan Yeoh, Genetics and Molecular Pathogenesis of Gastric Adenocarcinoma. Gastroenterology. ,vol. 149, pp. 1153- 1162 ,(2015) , 10.1053/J.GASTRO.2015.05.059