Photobiomodulation combined with photodynamic therapy using ruthenium phthalocyanine complexes in A375 melanoma cells: Effects of nitric oxide generation and ATP production
作者： Laísa Bonafim Negri , Tassia Joi Martins , Roberto Santana da Silva , Michael R. Hamblin
DOI: 10.1016/J.JPHOTOBIOL.2019.111564
关键词: Melanoma 、 Photodynamic therapy 、 Reactive oxygen species 、 Context (language use) 、 Photochemistry 、 Photosensitizer 、 Apoptosis 、 Chemistry 、 Nitric oxide 、 Singlet oxygen 、 Biophysics 、 Radiological and Ultrasound Technology 、 Radiation 、 Radiology Nuclear Medicine and imaging
摘要: Abstract Light irradiation has been used in clinical therapy for several decades. In this context, photobiomodulation (PBM) modulates signaling pathways via ROS, ATP, Ca2+, while photodynamic (PDT) generates reactive oxygen species by excitation of a photosensitizer. NO generation could be an important tool when combined with both kinds light therapy. By using metal-based compound, we found that PBM PDT beneficial cancer treatment option. We two types ruthenium compounds, ([Ru(Pc)], Pc = phthalocyanine) and trans-[Ru(NO)(NO2)(Pc)]. The UV–vis spectra complexes displayed band the 660 nm region. case 0.5 μM trans-[Ru(NO)(NO2)(Pc)], at Q-band reduced percentage viable human melanoma (A375) cells to around 50% as compared [Ru(Pc)]. hypothesized these results were due synergistic effect between singlet nitric oxide. Similar experiments performed (660 nm) (850 nm) induced more photocytotoxicity [Ru(Pc)] This was interpreted increasing cell metabolism (ATP production) consequent higher uptake phthalocyanine compounds efficient apoptosis. use photosensitizers may represent advance field
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Naoto Oku, Takayuki Ishii, ANTIANGIOGENIC PHOTODYNAMIC THERAPY WITH TARGETED LIPOSOMES Methods in Enzymology. ,vol. 465, pp. 313- 330 ,(2009) , 10.1016/S0076-6879(09)65016-3
Moumita Gangopadhyay, Tanya Singh, Krishna Kalyani Behara, S. Karwa, S. K. Ghosh, N. D. Pradeep Singh, Coumarin-containing-star-shaped 4-arm-polyethylene glycol: targeted fluorescent organic nanoparticles for dual treatment of photodynamic therapy and chemotherapy. Photochemical and Photobiological Sciences. ,vol. 14, pp. 1329- 1336 ,(2015) , 10.1039/C5PP00057B
Adewale O. Adeloye, Peter A. Ajibade, Synthesis, Characterization, Electrochemistry, and Spectroscopic Properties of Some Anthracenyl Functionalized Phthalocyanine Complexes of Ruthenium(II) Journal of Chemistry. ,vol. 2014, pp. 1- 8 ,(2014) , 10.1155/2014/257206
Timothy J Kinsella, Valdir C Colussi, Nancy L Oleinick, Claudio H Sibata, Photodynamic therapy in oncology. Expert Opinion on Pharmacotherapy. ,vol. 2, pp. 917- 927 ,(2001) , 10.1517/14656566.2.6.917
Tassiele A. Heinrich, Antonio Claudio Tedesco, Jon M. Fukuto, Roberto Santana da Silva, Production of reactive oxygen and nitrogen species by light irradiation of a nitrosyl phthalocyanine ruthenium complex as a strategy for cancer treatment Dalton Trans.. ,vol. 43, pp. 4021- 4025 ,(2014) , 10.1039/C3DT52217B
Mikhail G. Shapiro, Kazuaki Homma, Sebastian Villarreal, Claus-Peter Richter, Francisco Bezanilla, Infrared light excites cells by changing their electrical capacitance Nature Communications. ,vol. 3, pp. 736- 736 ,(2012) , 10.1038/NCOMMS1742
Mateusz Kwitniewski, Asta Juzeniene, Renata Glosnicka, Johan Moan, Immunotherapy: a way to improve the therapeutic outcome of photodynamic therapy? Photochemical and Photobiological Sciences. ,vol. 7, pp. 1011- 1017 ,(2008) , 10.1039/B806710D
Zênis Novais da Rocha, Renata Galvão de Lima, Fabio Gorzoni Doro, Elia Tfouni, Roberto Santana da Silva, Photochemical production of nitric oxide from a nitrosyl phthalocyanine ruthenium complex by irradiation with light in the phototherapeutic window Inorganic Chemistry Communications. ,vol. 11, pp. 737- 740 ,(2008) , 10.1016/J.INOCHE.2008.03.019
Zumira Aparecida Carneiro, Juliana Cristina Biazzotto de Moraes, Fernando Postalli Rodrigues, Renata Galvão de Lima, Carlos Curti, Zênis Novaes da Rocha, Michele Paulo, Lusiane Maria Bendhack, Antonio Claudio Tedesco, André Luiz Barboza Formiga, Roberto Santana da Silva, Photocytotoxic activity of a nitrosyl phthalocyanine ruthenium complex--a system capable of producing nitric oxide and singlet oxygen. Journal of Inorganic Biochemistry. ,vol. 105, pp. 1035- 1043 ,(2011) , 10.1016/J.JINORGBIO.2011.04.011
Michael J. Rose, Pradip K. Mascharak, Photoactive Ruthenium Nitrosyls: Effects of Light and Potential Application as NO Donors. Coordination Chemistry Reviews. ,vol. 252, pp. 2093- 2114 ,(2008) , 10.1016/J.CCR.2007.11.011