Serotonin dysregulation in Fragile X Syndrome: Implications for treatment
作者： Alicia C Hanson , Randi J Hagerman
关键词: Synaptic plasticity 、 Medicine 、 Fragile X syndrome 、 Psychiatry 、 Neuroscience 、 Serotonin reuptake inhibitor 、 Sertraline 、 Trinucleotide repeat disorder 、 Gene silencing 、 Serotonin 、 FMR1
摘要: Fragile X Syndrome (FXS) is a trinucleotide repeat disorder that results in the silencing of Mental Retardation 1 gene (FMR1), leading to lack FMR1 protein (FMRP). FMRP an mRNA-binding regulates translation hundreds mRNAs important for synaptic plasticity. Several these pathways have been identified and guided development targeted treatments FXS. Here we present evidence serotonin dysregulated FXS treatment with selective reuptake inhibitor (SSRI) sertraline may be beneficial individuals FXS, particularly early childhood.
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