Polymeric micelles of suberoylanilide hydroxamic acid to enhance the anticancer potential in vitro and in vivo.
作者： Sri Vishnu Kiran Rompicharla , Prakruti Trivedi , Preeti Kumari , Pratyusha Ghanta , Balaram Ghosh
关键词: In vivo 、 Micelle 、 Drug carrier 、 Bioavailability 、 Materials science 、 Pharmacology 、 Ethylene glycol 、 Drug delivery 、 In vitro 、 Biophysics 、 Caprolactone
摘要: Aim: To improve the bioavailability and anticancer potential of suberoylanilide hydroxamic acid (SAHA) by developing a drug-loaded polymeric nanomicellar system. Methods: SAHA-loaded Poly(ethylene glycol)-block-poly(caprolactone) (PEG-PCL) micelles were developed, physico-chemically characterized. In vitro cellular uptake, viability apoptosis-inducing ability SAHA-PEG-PCL investigated. vivo activity was evaluated in C57BL/6 mice-bearing tumor. Results: The had optimum size (∼130 nm) with an entrapment efficiency approximately 67%. induced stronger cell cycle arrest G2/M phase leading to higher rate apoptosis compared free SAHA. demonstrated significant tumor suppression SAHA vivo. Conclusion: physicochemical properties antitumor efficacy improved encapsulating micelles.
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