Aptamer-based 'point-of-care testing'.
作者： Subash CB Gopinath , Thangavel Lakshmipriya , Yeng Chen , Wai-Mei Phang , Uda Hashim
DOI: 10.1016/J.BIOTECHADV.2016.02.003
关键词: Flexibility (engineering) 、 SELEX Aptamer Technique 、 Point-of-care testing 、 Systematic evolution of ligands by exponential enrichment 、 Sensing applications 、 High sensitive 、 Computer science 、 Aptamer 、 Nanotechnology
摘要: Aptamers are single-stranded oligonucleotides that can be artificially generated by a method called Systematic evolution of ligands exponential enrichment (SELEX). The aptamers have been assessed for high-performance sensing applications due to their appealing characteristics. With either alone or complementing with antibodies, several high sensitive and portable sensors demonstrated use in 'point-of-care testing'. Due suitability flexibility, conjugated nanostructures utilized field applications. Moreover, more amenable chemical modifications, making them capable utilization most developed sensors. In this overview, we discuss novel, portable, aptamer-based strategies suitable
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