High and low heparin dose with heparin-coated cardiopulmonary bypass: activation of complement and granulocytes

摘要: Background. Cardiopulmonary bypass with heparin-coated circuits allows reduced amounts of systemic heparin. Heparin inhibits activation the complement cascade experimentally, but effects different levels heparin on and granulocytes in patients have remained unknown. Methods. Fifty-two undergoing coronary artery procedures were studied. completely coated surface-bound used for one group given low-dose (n = 17) (activated clotting time >250 seconds), was compared a second having normal high-dose >480 seconds) 18). A third control perfused ordinary uncoated full dose 17). Results. During cardiopulmonary bypass, C3 products C3b, iC3b, C3c increased markedly all three groups baseline, significantly less two (high dose, median maximal increase 58 arbitrary units (AU)/mL; low 48 AU/mL) (74 ( p Conclusions. Complement both independent level heparinization, whereas granulocyte only who received doses systemically administered The results indicate that moderate reduction may be an advantage regard to improved biocompatibility when using circuits.